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Nanopore single-molecule analysis of biomarkers: Providing possible clues to disease diagnosis

https://doi.org/10.1016/j.trac.2023.117060

Chen, Xiaohan; Zhou, Shuo; Wang, Yunjiao; Zheng, Ling; Guan, Sarah; Wang, Deqiang; Wang, Liang; Guan, Xiyun (May 2023, TrAC Trends in Analytical Chemistry)

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Single-Molecule Study on Interactions between Cyclic Nonribosomal Peptides and Protein Nanopore

https://doi.org/10.1021/acsabm.9b00961

Zhou, Shuo; Wang, Han; Chen, Xiaohan; Wang, Yunjiao; Zhou, Daming; Liang, Liyuan; Wang, Liang; Wang, Deqiang; Guan, Xiyun (December 2019, ACS Applied Bio Materials)

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Displacement chemistry-based nanopore analysis of nucleic acids in complicated matrices

https://doi.org/10.1039/c8cc07944g

Wang, Liang; Chen, Xiaohan; Zhou, Shuo; Roozbahani, Golbarg M.; Zhang, Youwen; Wang, Deqiang; Guan, Xiyun (December 2018, Chemical Communications)

To overcome the effect of other components of complicated biological samples on nanopore stochastic sensing, displacement chemical reaction was utilized to selectively extract the target nucleic acid from whole blood. Given its simplicity and high sensitivity for detecting nucleic acids, our developed displacement chemistry-based nanopore sensing strategy offers the potential for fieldable/point-of-care diagnostic applications.
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